الهيبسيدين وبعض المتغيرات البيوكيميائية في الأطفال العراقيين الذين يعانون من نقص هرمون النمو
محتوى المقالة الرئيسي
الملخص
الهيبسدين هو بروتين يحافظ على توازن الحديد في الجسم . المعلومات حول دور الهيبسدين في الفسيولوجيا المرضية المرتبطة بنقص هرمون النمو (GHD) شحيحة. تهدف الدراسة إلى تقييم ودراسة ارتباط الهيبسدين ببعض المتغيرات الكيميائية الحيوية: هرمون النمو (GH) ، والعامل الشبيه بالأنسولين -1 (IGF-1) ، والحديد ، وفيتامين د ، والفوسفاتيز القلوي (ALP) ، والكالسيوم ، والفوسفور ، و الفيريتين في الأطفال الذين يعانون من نقص هرمون النمو. الأطفال المشاركون في الدراسة والذين هم من المصابون بنقص هرمون النمو 60 والمتطوعون الأصحاء (60) في هذه الدراسة ، وتم جمع العينات من المركز الوطني للسكري والغدد الصم - الجامعة المستنصرية من الفترة من يناير إلى أبريل 2022. تم استخدام فحص المواد الماصة المرتبطة بالإنزيم (ELIZA) لقياس Hep. و تم استخدام المقايسة المناعية الإشعاعية الكيميائية لقياس GH و IGF-1 ، وأظهرت النتائج انخفاضًا ملحوظًا p <0.01 في مستوى الهيبسيدين في مصل مرضى GHD مقارنة بالأفراد الأصحاء ، وزيادة مستويات الحديد ، وهذا يمكن أن يفسر العلاقة العكسية بين الهيبسيدين والحديد. وهو أهم منظم لامتصاص الحديد ، وهذه الآلية تتم من خلال التأثير الوقائي للالتهاب ضد فقر الدم عن طريق زيادة التوافر الحيوي لـ (Fe). لذلك فإن هذه الدراسة التي أجريت لإعطاء فهم أفضل للمعلمات التي تؤثر على الأطفال المصابين بـ GHD و Hep. يمكن أن تكون معلمة يمكن الاعتماد عليها لإدارة أفضل لهؤلاء الأطفال.
Received 04/11/2022
Revised 19/05/2023
Accepted 21/05/2023
Published Online First 20/11/2023
تفاصيل المقالة
هذا العمل مرخص بموجب Creative Commons Attribution 4.0 International License.
كيفية الاقتباس
المراجع
Alhindawi GK, Al-Lami MQ, Al-Samarriae AY. Assessment of Levels of Metabolic Hormones and Lipid Profile in Growth Hormone Deficient Patients. IJS. 2020 ;26:732-41. https://doi.org/10.24996/ijs.2020.61.4.4
Tahir NT, Abdulsattar SA, Alkazzaz FF. Assessment of Obesity, Dyslipidemia, Hyperglycemia, and Pro-Inflammatory Cytokines as Cardiovascular Disease Risk Factors in Acromegaly Patients. Baghdad Sci. J. 2022 ;19(5):0976-. https://doi.org/10.21123/bsj.2022.6002
Haj-Ahmad LM, Mahmoud MM, Sweis NW, Bsisu I, Alghrabli AM, Ibrahim AM, et al. Serum IGF-1 to IGFBP-3 molar ratio: a promising diagnostic tool for growth hormone deficiency in children. J Clin Endocrinol Metab. 2023;108(4):986-94. https://doi.org/10.1210/clinem/dgac609
Taha OA. Serum Ghrelin Level in Children with Growth Hormone Deficiency and Those with Idiopathic Short Stature (Doctoral dissertation, Tanta University). https://doi.org/10.7537/marsnsj180420.05.
Ibba A, Guzzetti C, Casula L, Salerno M, Di Iorgi N, Allegri AM, et al. Reliability of clonidine testing for the diagnosis of growth hormone deficiency in children and adolescents. JCEM. 2018 ;89(6):765-70.https://doi.org/10.1111/cen.13845
Yang X, Kord-Varkaneh H, Talaei S, Clark CC, Zanghelini F, Tan SC, et al. The influence of metformin on IGF-1 levels in humans, a systematic review and meta-analysis. Pharmacol. Res. 2020;151(1):104588. https://doi.org/10.1016/j.phrs.2019.104588
Falihss,Alfartusie FS, Tahir NT. Evaluation of insulin-like growth factor-binding protein-3 (IGFBP-3) and some biochemical parameters in sera and saliva of children and adolescents with short stature.Degree of Master.Bagdad,Iraq: Mustansiriyah University;2020. Thesis.
Nemeth E, Ganz T. Hepcidin and iron in health and disease. Annu. Rev. Med. 2023 ;74:261-277. https://doi.org/10.1146/annurev-med-043021-032816
Khaleel FM, Muhi SA, Selman AD. Assessment of Pro Hepcidin and Related with Iron Profile on Hemodialysis Men Patients. Baghdad Sci. J.2016;13(1): 74-81. https://doi.org/10.21123/bsj.2016.13.1.0074
Ramos E, Kautz L, Rodriguez R, Hansen M, Gabayan V, Ginzburg Y, et al. Evidence for distinct pathways of hepcidin regulation by acute and chronic iron loading in mice. Comp. Hepatol. 2011 ;53(4):1333-1341.https://doi.org/10.1002/hep.24178
Caputo M, Pigni S, Agosti E, Daffara T, Ferrero A, Filigheddu N, et al. Regulation of GH and GH Signaling by Nutrients. Cells. 2021;10(6):1376. https://doi.org/10.3390/cells10061376
Ciresi A, Piazza G, Radellini S, Guarnotta V, Mineo MG, Giordano C. Growth hormone and hematopoiesis: a retrospective analysis on a large cohort of children with growth hormone deficiency. Growth Horm IGF Res. 2018 ;42(1):8-13. https://doi.org/10.1016/j.ghir.2018.07.005
Gat-Yablonski G, De Luca F. Effect of nutrition on statural growth. Horm Res Paediatr 2017;88(1):46-62. https://doi.org/10.1159/000456547
Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP, et al. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J. Clin. Endocrinol. Metab. 2011;96(7):1911-30. https://doi.org/10.1210/jc.2011-0385
Chang SW, Lee HC. Vitamin D and health-The missing vitamin in humans. PEDN. 2019 ;60(3):237-44. https://doi.org/10.1016/j.pedneo.2019.04.007
Alradeef MY. Association between Allelic Variations of-174G/C Polymorphism of Interleukin-6 Gene and Chronic Kidney Disease-Mineral and Bone Disorder in Iraqi Patients. Baghdad Sci. J.2020;17(4):1145-53. https://doi.org/10.21123/bsj.2020.17.4.1145
Danowitz M, Grimberg A. Clinical indications for growth hormone therapy. Adv Pediatr. 2022 ;69(1):203-17. https://doi.org/10.1016/j.yapd.2022.03.005
Harbison Md, Gertner Jm. Permissive Action Of Growth Hormone On The Renal Response To Dietary Phosphorus Deprivation. The. J. Clin. Endocrinol. Metab. 1990 ;70(4):1035-1040. https://doi.org/10.1210/jcem-70-4-1035
Malczewska-Lenczowska J, Sitkowski D, Surała O, Orysiak J, Szczepańska B, Witek K. The association between Iron and vitamin D status in female elite athletes. Nutrients. 2018 ;10(2):167. https://doi.org/10.3390/nu10020167
Algebori Am, Alosami Mh, Alhashimi Nh. Prevalence Of 25-Hydroxy Vitamin D Deficiency And Some Biochemical Parameters In Iraqi Patients With Rheumatoid Arthritis And Their Associations With Disease Activity. Asian J Pharm Clin Res . 2020;13(4):132-136. https://doi.org/10.22159/ajpcr.2020.v13i4.36759
Dzik KP, Kaczor JJ. Mechanisms of vitamin D on skeletal muscle function: oxidative stress, energy metabolism and anabolic state. Eur J Appl Physiol. 2019 ;119(4):825-39. https://doi.org/10.1007/s00421-019-04104-x
Durá-Travé T, Gallinas-Victoriano F. Vitamin D And Parathyroid Hormone During Growth Hormone Treatment. Child Teenagers. 2022 ;9(5):725. https://doi.org/10.1007/s00421-019-04104-x
Salerno G, Ceccarelli M, De Waure C, D’Andrea M, Buonsenso D, et al. Epidemiology and risk factors of hypovitaminosis D in a cohort of internationally adopted children: a retrospective study. Ital J Pediatr. 2018 ;44(1):1-4. https://doi.org/10.1186/s13052-018-0527-4
Panwar B, McCann D, Olbina G, Westerman M, Gutiérrez OM. Effect of calcitriol on serum hepcidin in individuals with chronic kidney disease: a randomized controlled trial. BMC Nephrol. 2018 ;19(1):1-8. https://doi.org/10.1186/s12882-018-0823-7
Alkabi HR, Alfatlawi WR, Aldabagh MA. Impact of Vitamin D Elements and Osteoporosis Factors in Postmenopausal Iraqi Women with T2DM.JASN. 2022;2(3):138. http://dx.doi.org/10.53293/jasn.2022.4483.1114
Vyas V, Kumar A, Jain V. Growth hormone deficiency in children: From suspecting to diagnosing. Indian Pediatr. 2017 ;54:955-60. https://doi.org/10.1007/s13312-017-1190-3
Sdogou T, Tsentidis C, Gourgiotis D, Marmarinos A, Gkourogianni A, Papassotiriou I, et al. Immunoassay‐based serum hepcidin reference range measurements in healthy children: differences among age groups. J Clin Lab Anal. 2015 ;29(1):10-4. https://doi.org/10.1002/jcla.21719
Pandrangi SL, Chittineedi P, Chikati R, Lingareddy JR, Nagoor M, Ponnada SK. Role of dietary iron revisited: In metabolism, ferroptosis and pathophysiology of cancer. Am J Cancer Res. 2022;12(3):974. https://pubmed.ncbi.nlm.nih.gov/35411219
Krygier A, Szczepanek-Parulska E, Cieślewicz M, Wrotkowska E, Chanaj-Kaczmarek J, Ruchała M. Iron Homeostasis and Hepcidin Concentration in Patients With Acromegaly. Front. Endocrinol. 2021;12:788247. https://doi.org/10.3389%2Ffendo.2021.788247
Tang D, Chen X, Kang R, Kroemer G. Ferroptosis: molecular mechanisms and health implications. Cell Res. 2021;31(2):107-125. https://doi.org/10.1038/s41422-020-00441-1
Raha AA, Biswas A, Henderson J, Chakraborty S, Holland A, Friedland RP, et al. Interplay of ferritin accumulation and ferroportin loss in ageing brain: implication for protein aggregation in down syndrome dementia, Alzheimer’s, and Parkinson’s diseases. Int J Mol Sci. 2022 ;23(3):1060. https://www.mdpi.com/1422-0067/23/3/1060
Diepeveen LE, Laarakkers CM, Martos G, Pawlak ME, Uğuz FF, Verberne KE, et al. Provisional standardization of hepcidin assays: creating a traceability chain with a primary reference material, candidate reference method and a commutable secondary reference material. Clin Chem Lab Med. 2019 ;57(6):864-872. https://doi.org/10.1515/cclm-2018-0783
Vreugdenhil M, Akkermans MD, van der Merwe LF, van Elburg RM, van Goudoever JB, Brus F. Prevalence of zinc deficiency in healthy 1–3-year-old children from three western european countries. Nutrients. 2021 ;13(11):3713. https://doi.org/10.3390/nu13113713
Šimetić L, Zibar L. Laboratory use of hepcidin in renal transplant recipients. Biochemia Medica. 2016 ;26(1):34-52. https://doi.org/10.11613/BM.2016.003
Hernik A, Szczepanek-Parulska E, Filipowicz D, Abdolall A, Borowczyk M, Wrotkowska E, et al. The Hepcidin Concentration Decreases in Hypothyroid Patients With Hashimoto's Thyroiditis Following Restoration of Euthyroidism. Sci Rep .2019;9(1) :16222. https://doi.org/10.1038/s41598-019-527153.
Karoriya AK, Jain A, Kumar R, Shakkarpude J. Hepcidin: An emerging hormone in iron homeostasis: A review. IJCS. 2021;9(1):2469-74. http://dx.doi.org/10.22271/chemi.2021.v9.i1ai.11600
Krygier A, Szczepanek-Parulska E, Filipowicz D, Ruchała M. Changes in serum hepcidin according to thyrometabolic status in patients with Graves’ disease. Endocr Connect. 2020 ;9(3):234. https://doi.org/10.1530/EC-20-0017
Goto K, Kojima C, Kasai N, Sumi D, Hayashi N, Hwang H. Resistance exercise causes greater serum hepcidin elevation than endurance (cycling) exercise. Plos one. 2020 ;15(2):0228766. https://doi.org/10.1371/journal.pone.0228766
Harada K, Hanayama Y, Obika M, Itoshima K, Okada K, Otsuka F. Clinical relevance of insulin-like growth factor-1 to cardiovascular risk markers. Androg. Aging Male, Proc. Workshop. 2020 ;23(5):1030-8. https://doi.org/10.1080/13685538.2019.1657083
Claustres M, Chatelain P, Sultan C. Insulin-like growth factor I stimulates human erythroid colony formation in vitro. J Clin Endocrinol Metab. 1987 1;65(1):78-82. https://doi.org/10.1210/jcem-65-1-78
Ece A, Çetinkaya S, Ekşioğlu S, Şenel S, Özkasap S, Giniş T, et al. Kidney growth and renal functions under the growth hormone replacement therapy in children. Ren Fail. 2014 ;36(4):508-513. https://doi.org/10.3109/0886022X.2013.875834
Lee J, Yoon J, Kang MJ, Lee YA, Lee SY, Shin CH, et al. Influence of body mass index on the growth hormone response to provocative testing in short children without growth hormone deficiency. J. Korean Med. Sci.2013 ;28(9):1351-1355. https://doi.org/10.3346/jkms.2013.28.9.1351
Amato A, Santoro N, Calabro P, Grandone A, Swinkels DW, et al. Effect of body mass index reduction on serum hepcidin levels and iron status in obese children. Int J Obes Suppl. 2010 ;34(12):1772-1774. https://doi.org/10.1038/ijo.2010.204
Thakur DS, Bhagwat NM, Bhide MM, Yerawar CG, Ghanekar GA, Sonawane AB, et al. Clonidine stimulation test: Is single best time point, convenient yet efficacious. Indian J. Endocrinol. Metab. 2018 ;22(4):511. https://doi.org/10.4103/ijem.IJEM_101_18
Ciresi A, Cicciò F, Giordano C. High prevalence of hypovitaminosis D in Sicilian children affected by growth hormone deficiency and its improvement after 12 months of replacement treatment. J. Endocrinol. Invest.2014 ;37(7):631-8. https://doi.org/10.1007/s40618-014-0084-7
Ciresi A, Giordano C. Vitamin D across growth hormone (GH) disorders: from GH deficiency to GH excess. Growth Horm. IGF Res. 2017 ;33:35-42. https://doi.org/10.1016/j.ghir.2017.02.002
Schroth RJ, Jeal NS, Kliewer E, Sellers EA. The relationship between vitamin D and severe early childhood caries: a pilot study. Int J Vitam Nutr Res. 2012 ;82(1):53-62. https://doi.org/10.1024/0300-9831/a000094
Goltzman D. Functions of vitamin D in bone. Histochem. Cell Biol. 2018 ;149(4):305-12. https://doi.org/10.1007/s00418-018-1648-y
Esposito S, Leonardi A, Lanciotti L, Cofini M, Muzi G, Penta L. Vitamin D and growth hormone in children: a review of the current scientific knowledge. J Transl Med.2019 ;17(1):1-8. https://doi.org/10.1186/s12967-019-1840-4
Uwitonze AM, Rahman S, Ojeh N, Grant WB, Kaur H, Haq A, Razzaque MS. Oral manifestations of magnesium and vitamin D inadequacy. J Steroid Biochem Mol Biol. 2020 ;200:105636. https://doi.org/10.1016/j.jsbmb.2020.105636
Alhashimi NH, Al-Gebori AM, Alosami MH. Evaluation of the Human Pulmonary Activation-Regulated Chemokine (CCL18/PARC) and Alkaline Phosphatase (ALP) Levels in Iraqi Patients with Rheumatoid Arthritis. IJS. 2020 ;26:713-9. https://doi.org/10.24996/ijs.2020.61.4.1