دراسة التاثير الوراثي لنبات الخله داخل جسم الكائن الحي على معامل الانقسام الخلوي,تكوين النوى الصغيرة و تحطم الدنا الوراثي (DNA )
DOI:
https://doi.org/10.21123/bsj.2024.9034الكلمات المفتاحية:
مضادات السرطان، المستخلص الميثانولي، النباتات الطبية، ذكر الفأر، معامل الانقسام الاستوائيالملخص
صممت هذه الدراسة للكشف عن التاثير الوراثي للمستخلص الميثانولي لنبات الخلة على معامل الانقسام الخلوي,تكون النوى الصغيرة و مدى تاثيره على تحطم الدنا الوراثي في الفئران المستحثة بعقار الميتوزانترون (المضاد للسرطان). استخدمت في هذه الدراسة اربعه مجاميع للفئران: المجموعه الاولى(السيطرة الموجبة )الفئران المعاملة بعقار الميتوزانترون بتركيز (0,008 ملغم\فارة) والمجموعه الثانية (السيطرة السالبة) الفئران الغير معامله اما المجوعه الثالثة والرابعه كانت الفئران المعاملة بالعقار لليومين الاول والثاني ومن اليوم 3 الى 7 عوملت الفئران بالمسخلص النباتي يتركيزي (50 و 100 ملغم\كغم) على التوالي. اظهرت النتائج قابلية النبات على زيادة الانقسام الخلوي بالمقارنه مع السيطرة الموجبة والسالبة كما اظهرت قابلية النبات على خفض نسبة تكون النوى الصغيرة وتحطم الدنا بالمقارنه ايضا مع السيطرتين الموجبة والسالبة.
Received 06/05/2023
Revised 08/09/2023
Accepted 10/09/2023
Published Online First 20/01/2024
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