تأثيرمكملات فيتامين د على محور الهيبسيدين/الفيروبورتين وتعبير مستقبلات فيتامين د في الفئران المغذاه على وجبة عالية الدهون-عالية الفركتوز

المؤلفون

  • هاجر مسعد سعد عبد الجواد قسم الكيمياء الحيوية والتغذية، كلية البنات للآداب والعلوم والتربية، جامعة عين شمس، القاهرة، مصر.
  • هبة عادل عبد الحميد بركات قسم الكيمياء الحيوية والتغذية، كلية البنات للآداب والعلوم والتربية، جامعة عين شمس، القاهرة، مصر.
  • ايمان حسن عبد العزيز شرف قسم الكيمياء الحيوية والتغذية، كلية البنات للآداب والعلوم والتربية، جامعة عين شمس، القاهرة، مصر.
  • نورهان جمال الرحماني قسم الكيمياء الحيوية والتغذية، كلية البنات للآداب والعلوم والتربية، جامعة عين شمس، القاهرة، مصر. https://orcid.org/0000-0002-7519-5477

DOI:

https://doi.org/10.21123/bsj.2024.9626

الكلمات المفتاحية:

محور الهيبسيدين- فيروبورتن, توازن الحديد ,المتلازمة الايضية ,فيتامين د ,مستقبلات فيتامين د.

الملخص

يعد إستهداف محور الهيبسيدين- فيروبورتن هو الآلية الرئيسية المشاركة في الصحه الايضيه. تهدف هذه الدراسه إلي دراسة العلاقه المتشابكه بين حالة فيتامين د وتوازن الحديد في متلازمة التمثيل الغذائي الناجم عن إتباع نظام غذائي عالي الدهون وعالي الفركتوز في الجرذان .كانت المجموعات التجريبيه علي النحو التالي G1 التحكم السلبي ، G2التحكم الموجب ، G3 و G4(نظام غذائي متوازن ومدعم بفيتامين د 12و24 ميكروجرام / كجم من وزن الجسم علي التوالي مرتين في الاسبوع ). G5 و G6(نظام غذائي عالي الدهون و عالي الفركتوزلومدعم بفيتامين د 12و24 ميكروجرام / كجم من وزن الجسم علي التوالي مرتين في الاسبوع). تم تقييم العديد من العوامل البيوكيميائيه والجزيئيه والنسيجيه في السيرم وانسجة الكبد . أظهرت النتائج أن تناول فيتامين د عدل بشكل كبير توازن الحديد المضطرب الناتج عن النظام الغذائي العالي في الدهون والفركتوز من خلال تنظيم محور الهيبسيدين-الفيروبروتين مما يؤدي إلي تحسن كبير في مستوي الحديد في السيرم ، كما أن تناول فيتامين د يعزز حالة مضادات الاكسده عن طريق تقليل نشاط مستوى الMDA وزيادة نشاط HO-1 في السيرم بالإضافه إلي تنظيم التعبير الجيني لNrf2 . كما أنه يخفف من إرتفاع المؤشرات الحيويه الإلتهابيه  في السيرم و مستوي الresistin بينما يزيد بشكل ملحوظ من مستوي الadiponectin في السيرم ، علاوة علي ذلك ، تم تنظيم التعبير الجيني لمستقبلات فيتامين د في أنسجة الكبد وزيادة نسبة فيتامين د في السيرم بشكل ملحوظ مما أدي إلي تحسين مقاومة الانسولين وتقليل نسبة الدهون في السيرم . تظهر النتائج المجهريه وجود إرتشاح دهني بينما بعد تناول فيتامين د حدث تحسن في أنسجة الكبد .

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1.
تأثيرمكملات فيتامين د على محور الهيبسيدين/الفيروبورتين وتعبير مستقبلات فيتامين د في الفئران المغذاه على وجبة عالية الدهون-عالية الفركتوز. Baghdad Sci.J [انترنت]. [وثق 22 يوليو، 2024];22(1). موجود في: https://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/9626