الكيمياء اللاعضوية التناسقية تحضير وتشخيص ودراسة الفعالية البايولوجية لمعقدات جديدة لبعض العناصر الانتقالية مع قواعد شيف مشتقة من احدى معوضات الأنتي بايرين
DOI:
https://doi.org/10.21123/bsj.2024.9715الكلمات المفتاحية:
معوضات 4-امينو انتي بايرين، الفعالية البايولوجية،ليكاند قاعدة شيف، معقدات المربع المستوي، الفلزات الانتقالية.الملخص
حضرت مجموعة من المعقدات ذات الصيغة [M (L)Cl2] حيث M= Co+2,Ni+2,Cu+2,Zn+2, Cd+2
L= (Z)-4-((1-(H-indol-3-yl)ethylidene)amino)1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one.
من ليكاند قاعدة شيف مشتق من المركب 4-امينو انتبيرين مع 3-استايل اندول كما تم تشخيص الليكاند والمعقدات المحضرة بالتحليل الدقيق للعناصر واطياف الاشعة تحت الحمراء وطيف الرنين النووي المغناطيسي وقياسات الحساسية المغناطيسية وتحليل المحتوى الفلزي بطريقة الامتصاص الذري فضلا عن دراسة الفعالية البايولوجية للمركبات المحضرة. اثبتت القياسات المستخدمة ان الليكاند المحضر يتناسق مع ايون الفلز المركزي من خلال ذرة اوكسجين مجموعة الكاربونيل وذرة نتروجين مجموعة الازوميثين ويتخذ معقد النيكل المحضر الشكل الفراغي مربع مستوي اما بقية المعقدات فتتخذ الشكل الفراغي رباعي السطوح ،كما تبين ان المعقدات المحضرة غير موصلة الكتروليتيا واثبتت المركبات المحضرة فعالية عالية كمضاد بكتريا لبعض أنواع بكتريا كرام الموجبة والسالبة.
Received 27/09/2023
Revised 07/01/2024
Accepted 09/01/2024
Published Online First 20/10/2024
المراجع
- Wannas NM, Al‐Hamdani AAS, Al Zoubi, W. Spectroscopic characterization for new complexes with 2, 2′‐(5, 5‐dimethylcyclohexane‐1, 3‐diylidene) bis (azan‐1‐yl‐1‐ylidene) dibenzoic acid. J Phys Org Chem. 2020; 33(11): 1-12.https://doi.org/10.1002/poc.4099
- Bozejewicz D, Osmiałowski B, Kaczorowska MA,Witt K. 2, 6-Bis ((benzoyl-R) amino) pyridine (R= H, 4-Me, and 4-NMe2) Derivatives for the Removal of Cu (II), Ni (II), Co (II), and Zn (II) Ions from Aqueous Solutions in Classic Solvent Extraction and a Membrane Extraction. Membranes. 2021; 11(4): 1-9. https://doi.org/10.3390/membranes11040233
- Al-Shemary RKR, Alkam HH, AlWan WM. .Implementations of Transition Metal Complexes of Schiff Base Derived Ampyrone. Der Pharm Lett. 2021; 13(6): 17-48. https://2u.pw/LFjCdrS.
- Rasyda YA, Widowati MK, Marliyana SD, Rahardjo SB. Synthesis, Characterization and Antibacterial Properties of Nickel (II) Complex with 4-Aminoantipyrine Ligand. Indones J Chem.2021; 21(2): 391-399. https://doi.org/10.22146/ijc.56552
- Ibraheem IH, Sadiq AS, Al-Tameemi M, Alias MF. Synthesis, Spectral Identification, Antibacterial Evaluationand Theoretical Study of Co, Fe, Rh and Pd Complexes for 2-benzoylthiobenzimidazol. Baghdad Sci J. 2022; 19(6): 1326-1326. https://dx.doi.org/10.21123/bsj.2022.6704
- Ghosh P, Dey SK, Ara MH, Karim R, Islam ABM. A review on synthesis and versatile applications of some selected Schiff bases with their transition metal complexes. Egypt J Chem. 2019; 62(Special Issue (Part 2) Innovation in Chemistry: 523-547. https://dx.doi.org/10.21608/ejchem.2019.13741.1852
- Ashrafuzzaman MD, Camellia FK, Mahmud AA, Pramanik MD, Nahar K, HAQUE M. Bioactive mixed ligand metal complexes of Cu (II), Ni (II), and Zn (II) ions: synthesis, characterization, antimicrobial and antioxidant properties. J Chil Chem Soc.2021; 66(3): 5295-5299 http://dx.doi.org/10.4067/S0717-97072021000305295
- Hamza IS, Mahmmoud WA, Al-Hamdani AA, Ahmed SD, Allaf AW, Al, et al. Synthesis, characterization, and bioactivity of several metal complexes of (4-Amino-N-(5-methyl-isaxazol-3-yl)-benzenesulfonamide. Inorg Chem Commun. 2022; 144(109776): 1-23.https://doi.org/10.1016/j.inoche.2022.109776
- Janabi ZMA, Alsalami HSJ, Al-Khafaji ZS, Hussien SA. Increasing of the corrosion resistance by preparing the trivalent nickel complex. Egypt J Chem. 2022; 65(6): 193-198. https://doi.org/10.21608/ejchem.2021.100733.4683
- Nabhan KJ, Mahdi AS, Al-Zaidi BH, Ismail AH, Nasif ZN. New tetra-dentate schiff base ligand N2O2 and its complexes with some of metal ions: preparation, identification, and studying their enzymatic and biological activities. Baghdad Sci J. 2022; 19(1): 0155-0155. http://dx.doi.org/10.21123/bsj.2022.19.1.0155
- Hashim DJ, Mahdi SM. Preparation, Characterization, and Biological Study of New Halogenated Azo-Schiff Base Ligands and Their Complexes. J Med Chem. Sci. 2022; 6: 1555-1576. https://doi.org/10.26655/JMCHEMSCI.2023.7.8
- Al-Shaheen AJ, Al-Bayati MR, Ali AM. Synthesis and characterization some of metal (II) complexes with 2-(6-methoxy naphthalene-2-yl) propionic acid (2-hydroxy benzylidene) hydrazone. Int J Enhence Sci Technol Eng. 2017; 6(11): 10-16.
- Chandra S, Raizada S, Tyagi M, Sharma PK. Spectroscopic and biological approach of Ni (II) and Cu (II) complexes of 2-pyridinecarboxaldehyde thiosemicarbazone. Spectrochim Acta A Mol Biomol Spectrosc. 2008; 69(3): 816-821. https://doi.org/10.1016/j.saa.2007.05.033.
- Alattar RA, Hassan ZM, Abass SK, Ahmad LM. Synthesis, characterization and study the photodecolorization of Schiff base Fe (III) complex in ZnO/Uv-A light system. AIP Conf Proc. 2020; 2290(1): 030032-10. https://doi.org/10.1063/5.0027611
- Numan,AT, Atiyah EM, Fayad AA, Namuq IB. Synthesis, Characterization and Study of Antibacterial Activity of a New Schiff Base Ligand and Its Complexes with Co (II), Ni (II), Cu (II), Cd (II) and Hg (II) Metal Ions. Baghdad Sci J. 2016; 13(2): 0153-0153. http://dx.doi.org/10.21123/bsj.2016.13.2.2NCC.0351
- Saranya J, Kirubavath SJ, Chitra S, Zarrouk A, Kalpana K, Lavany K, et al. Tetradentate Schiff Base complexes of transition metals for antimicrobial activity. Arab J Sci Eng. 2020; 45: 4683-4695. https://doi.org/10.1007/s13369-020-04416-7
- Shaalan N, Preparation, Spectroscopy, Biological Activities and Thermodynamic Studies of New Complexes of Some Metal Ions with 2-[5-(2-Hydroxy-Phenyl)-1, 3, 4-Thiadiazol-2-Ylimino]-Methyl-Naphthalen-1-Ol. Baghdad Sci J. 2022; 19(4): 829-837. http://dx.doi.org/10.21123/bsj.2022.19.4.0829
- Jamil W, Solangi S, Ali M, Taha KMKM, Khuhawar M Y. Syntheses, characterization, in vitro antiglycation and DPPH radical scavenging activities of isatin salicylhydrazidehydrazone and its Mn (II), Co (II), Ni (II), Cu (II), and Zn (II) metal complexes. Arabian Journal of Chemistry.2019; 12(8):2262-2269 http://dx.doi.org/10.1016/j.arabjc.2015.02.015
- Ali A, Elasala GS, Mohamed EA, Kolkaila SA. Spectral, thermal studies and biological activity of pyrazinamide complexes. Heliyon.2019; 5(11): 1-10. https://doi.org/10.1016/j.heliyon.2019.e02912
- Reda S M, Al-Hamdani A A S. Mn (II), Fe (III), Co (II) and Rh (III) complexes with azo ligand: Synthesis, characterization, thermal analysis and bioactivity. Baghdad Sci J. 2023; 20(3): 642-660. https://dx.doi.org/10.21123/bsj.2022.7289
- Kareem MJ, Al-Hamdani AAS, Ko YG, Al Zoubi W, Mohammed SG. Synthesis, characterization, and determination antioxidant activities for new Schiff base complexes derived from 2-(1H-indol-3-yl)-ethylamine and metal ion complexes. J Mol Struct. 2021; 1231: 129669. https://doi.org/10.1016/j.molstruc.2020.129669
- Al-Hassani R A. Synthesis, Characterization, Antimicrobial and Theoretical Studies of V (IV), Fe (III), Co (II), Ni (II), Cu (II), and Zn (II) Complexes with Bidentate (NN) Donar Azo Dye Ligand. Baghdad Sci J. 2016; 13(4): 793-805. http://dx.doi.org/10.21123/bsj.2016.13.4.0793
- Sabah AA, Ameen AM, Al-Daher A. Metal Complexes of Bis (2, 6-diamine pyridine 2, 5-hexanedione) Macrocyclic Schiff-Base Ligand: Preparation, Characterization and thermal study. Iraqi J Sci. 2022; 63(5): 1885-1893. https://doi.org/%2010.24996/ijs.2022.63.5.3
- Al-Hamdani AA, Shaalan ND, Bakir SR, Mohammed MS. Preparation, spectral characterization, structural study, and evaluation of antibacterial activity of Schiff base complexes for VOII, CrIII, MnII, ZnII, CdII and CeIII. Baghdad Sci J. 2015; 12(2): 350-361.
- Al-qasii NAR, Ali TB, Zaied M. Synthesis and Characterization of a Novel Azo-Dye Schiff Base and Its Metal Ion Complexes Based on 1, 2, 4-Triazole Derivatives. Indones J Chem. 2023; 23(6): 1555-1566. https://doi.org/10.22146/ijc.83509
- Ali AM, Mohammed HA, Jasim ZU, Abed RR. Characterization and Antibacterial Evaluation of New Complexes of Nicotinamide semicarbazon Manganese (II), Zinc (II), Silver (I) Synthesizes. Res J Pharm Technol. 2023; 16(2): 539-544. https://doi.org/ 10.52711/0974-360X.2023.00092
- Tyagi M, Chandra S, Akhtar J, Chand D. Modern spectroscopic technique in the characterization of biosensitive macrocyclic Schiff base ligand and its complexes: Inhibitory activity against plantpathogenic fungi. Spectrochim Acta A Mol Biomol Spectrosc.2014; 118: 1056-1061. https://doi.org/10.1016/j.saa.2013.09.124
- Dakore SD ,Kamble VT. synthesis of Biological Active N2O2 Type of Navel Schiff base Metai Complexes Derived from 4- Amino Antipyrin using Tea. J Chem Pharm Res. 2016; 8(11): 211-215.
- Sherif SH, Kure DA, Moges EA, Argaw B. Synthesis., Characterization, and Antibacterial, Activity, Evaluation of 4-amino Antipyrine. Derivatives and Their Transition Metal Complexes. Am J Biosci Bioeng. 2021; 9(1): 8-12. https://doi.org/ 10.11648/j.bio.20210901.12
- Mohanambal D, Sridev G, Arul antony S, Angayarkani R. review: a recent review in applications of heterocyclic compounds as antimicrobial agent. Asian J Pharm Clin Res. 2018; 11(12): 66-74 . https://doi.org/10.22159/ajpcr.2018.v11i12.26890
- Kareem IK, Waddai FY, Abbas G J. Synthesis, Characterization and biological activity of Some Transition Metal Complexes with New Schiff Base Ligand Type (NNO) Derivative from Benzoin. J Pharm Sci Rese. 2019; 11(1): 119-124.
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الحقوق الفكرية (c) 2024 Zeena U. Jasim, Amal M. Ali , Heba A. Mohammed , Maher A. Mohammed
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