Preparation and characterization and biological activity of new complexes for some transition elements with Schiff bases derived from one antipyrine substitute
DOI:
https://doi.org/10.21123/bsj.2024.9715Keywords:
4-aminoantipyrin substitute, Biological activity, Schiff base ligand, Square planar complexes, Transition metals.Abstract
A group of divalent complexes was prepared in the formula [M( L)Cl2] when M=Co+2, Ni+2, Cu+2, Zn+2, and Cd+2 L= (Z)-4-((1-(H-indol-3-yl)ethylidene)amino)1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one. The Schiff base ligand is prepared by reacting 4-aminoantipyrine with 3-acetylindol. The prepared ligand and complexes were identified by elemental analysis, an infrared spectrometer, the nuclear magnetic resonance spectrum, molar electrical conductivity, electronic spectra, magnetic susceptibility, atomic absorption of the elements, and biological efficiencies. The measurements showed that the synthesized ligand interacts with the central metal ion through the oxygen carbonyl group and nitrogen azomethine atoms, that the coordination of the prepared complexes has a square planar nickel complex and the tetrahedral geometry of other complexes, and that these complexes are non-electrolytic.The synthesized compounds have good antibacterial activity against Gram-negative bacteria, represented by Pseudomonas savastanoi, and Gram-positive bacteria, represented by Bacillus subtilis.
Received 27/09/2023
Revised 07/01/2024
Accepted 09/01/2024
Published Online First 20/10/2024
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Copyright (c) 2024 Zeena U. Jasim, Amal M. Ali , Heba A. Mohammed , Maher A. Mohammed
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