الارتباط المحتمل بين حدوث سرطان الثدي لدى المريضات العراقيات وتعدد الأشكال rs861539 وفيتامين د والفيتامينات المضادة للأكسدة

المؤلفون

  • اقبال حنش ضفير قسم تقنيات المختبرات الطبية، المعهد التقني الصويرة، الجامعة التقنية الوسطى، واسط- العراق https://orcid.org/0000-0002-0652-1523

DOI:

https://doi.org/10.21123/bsj.2024.10456

الكلمات المفتاحية:

مضادات الأكسدة، سرطان الثدي، الحديد، فيتامين د، XRCC3.

الملخص

سرطان الثدي هو السبب الرئيسي للوفيات بين الإناث. قد تعزى الاختلافات في قدرة إصلاح الحمض النووي وما يترتب على ذلك من استعداد وراثي لبعض الأورام الخبيثة إلى تعدد الأشكال في جينات إصلاح الحمض النووي. كانت هناك دراسات قليلة وغير حاسمة حول العلاقة بين مستويات الفيتامينات والمعادن والغذاء في الدم ونشوء سرطان الثدي. لقد استكشفنا الارتباطات بين الأشكال المتعددة (rs861539) في جين XRCC3 وفيتامين د. في أحد المستشفيات، أجرينا أيضًا تحقيقًا لتقييم علاقات الفيتامينات د، ه، ج، والحديد مع سرطان الثدي. تكون مجتمع الدراسة من ثلاثين شخصا طبيعيا سليما وستين مريضة بسرطان الثدي. لغرض تقدير الفيتامينات د، ه، ج وبعض المعادن والحديد تم سحب الدم الوريدي من المرضى والضوابط وباستخدام الإجراءات القياسية. تم تحديد SNP (rs861539) في جين XRCC3 بواسطة RFLP-PCR. وقد اكتشف أن متوسط تركيزات الفيتامينات D وE وC كانت أقل لدى المرضى الإناث مقارنة بالأصحاء، ولكن تركيز الحديد في الدم كان أكبر بكثير في المرضى الذين يعانون من سرطان الثدي. كما أظهرت الدراسة الحالية وجود علاقة قوية بين فيتامين د والفيتامينات المضادة للأكسدة (فيتامينات أ، ه، ج، وبيتا كاروتين) والسيلينيوم وسرطان الثدي لدى الإناث في العراق. ومع ذلك، لم يتم اكتشاف أي علاقة ذات معنى بين تعدد أشكال XRCC3 (rs861539) وخطر الإصابة بسرطان الثدي. بالإضافة إلى ذلك، فإنه يعني أن ارتفاع مستويات الحديد في الدم يمكن أن يزيد من خطر الإصابة بسرطان الثدي عن طريق زيادة الأكسدة.

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الارتباط المحتمل بين حدوث سرطان الثدي لدى المريضات العراقيات وتعدد الأشكال rs861539 وفيتامين د والفيتامينات المضادة للأكسدة. Baghdad Sci.J [انترنت]. [وثق 23 ديسمبر، 2024];22(7). موجود في: https://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/10456