Potential association between the incidence of breast cancer in female Iraqi patients and the rs861539 polymorphism, vitamin D, and antioxidant vitamins
DOI:
https://doi.org/10.21123/bsj.2024.10456Keywords:
Antioxidants, Breast Cancer, Iron, Vitamin D, XRCC3.Abstract
Breast cancer is the main cause of mortality for females. Variations in DNA repair capacity and consequent hereditary predisposition to certain malignancies may be attributed to polymorphisms in DNA repair genes. There have been few and inconclusive studies on the relationship between blood levels of vitamins and minerals and food and the genesis of breast cancer. We explored correlations between polymorphisms (rs861539) and vitamin D. In addition, the effects of vitamins D, E, C, and iron on breast cancer were examined. The study population consisted of thirty healthy normal persons and sixty breast cancer patients. For the purpose of estimating vitamins (D, E, C), as well as minerals and iron, venous blood was drawn from all samples utilizing standard procedures. The single nucleotide polymorphism (rs861539) were determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique. It was discovered that, the mean concentrations of vitamins D, E, and C were lower in female patients compared to healthy controls, but that the serum iron concentration was significantly greater in patients with breast cancer. Also the current study showed a strong correlation between vitamin D, antioxidant vitamins (vitamins A, E, C, and β-carotene), and selenium with breast cancer in the female population of Iraq. Nonetheless, no meaningful correlation was discovered between the polymorphism of rs861539 and the breast cancer risk. Additionally, it implies that increased oxidative stress caused by elevated serum iron levels may increase the risk of breast cancer.
Received 14/12/2024
Revised 12/07/2024
Accepted 14/07/2024
Published Online First 20/12/2024
References
Parvez E, Chu M, Kirkwood D, Doumouras A, Levine M, Bogach J. Patient reported symptom burden amongst immigrant and Canadian long-term resident women undergoing breast cancer surgery. Breast Cancer Res Treat. 2023; 199(3): 553-563. https://doi.org/10.1007/s10549-023-06938-8.
Tao X, Li T, Gandomkar Z, Brennan PC, Reed WM. Incidence, mortality, survival, and disease burden of breast cancer in China compared to other developed countries. Asia Pac J Clin Oncol. 2023; 19(6): 645-654. https://doi.org/10.1111/ajco.13958.
Azadnajafabad S, Saeedi Moghaddam S, Mohammadi E, Rezaei N, Rashidi MM, Rezaei N, et al. Burden of breast cancer and attributable risk factors in the North Africa and Middle East region, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019. Front Oncol. 2023; 13: 1132816. https://doi.org/10.3389/fonc.2023.1132816.
Shakor JK. Assessment of the Iraqi Breast Cancer Early Detection and Downstaging Program: Mammography Cancer Detection Rate. Passer J Basic Appl Sci. 2023; 5(2): 272-277. https://doi.org/10.24271/PSR.2023.380223.1224.
De Cicco P, Catani MV, Gasperi V, Sibilano M, Quaglietta M, Savini I. Nutrition and breast cancer: a literature review on prevention, treatment and recurrence. Nutrients. 2019; 11(7): 1514. https://doi.org/10.3390/nu11071514.
Rock CL, Thomson CA, Sullivan KR, Howe CL, Kushi LH, Caan BJ, et al. American Cancer Society nutrition and physical activity guideline for cancer survivors. CA: a Cancer. J Clin. 2022; 72(3): 230-262. https://doi.org/10.3322/caac.21719.
Han X, Zhao R, Wang Y, Ma H, Yu M, Chen X, et al. Dietary Vitamin A Intake and Circulating Vitamin A Concentrations and the Risk of Three Common Cancers in Women: A Meta-Analysis. Oxid Med Cellular Long. 2022; 2022(1): 7686405. https://doi.org/10.1155/2022/7686405.
Yu W, Tu Y, Long Z, Liu J, Kong D, Peng J, et al. Reactive oxygen species bridge the gap between chronic inflammation and tumor development. Oxid Med Cellular Long. 2022; 2022(1): 2606928.https://doi.org/10.1155/2022/2606928.
Hmood AM, Alwan IF, Alzahera NA, Abaas R, Mohsen G, Mohmed T. Determination Oxidant-Antioxidant Enzyme and some Trace Elements in Breast Cancer in Baghdad City. Baghdad Sci. J. 2014; 11(2): 350-357. https://doi.org/10.21123/bsj.2014.11.2.350-357.
Islam MR, Akash S, Jony MH, Alam MN, Nowrin FT, Rahman MM, et al. Exploring the potential function of trace elements in human health: a therapeutic perspective. Mol Cell Biochem. 2023; 478(10): 2141-2171. https://doi.org/10.1007/s11010-022-04638-3.
Tsang JY, Tse GM. Update on triple‐negative breast cancers–highlighting subtyping update and treatment implication. Histopathology. 2023; 82(1): 17-35. https://doi.org/10.1111/his.14784
. Rajagopal T, Seshachalam A, Rathnam KK, Talluri S, Venkata BS, Dunna NR. Homologous recombination DNA repair gene RAD51, XRCC2 & XRCC3 polymorphisms and breast cancer risk in South Indian women. Plos one. 2022; 17(1): e0259761. https://doi.org/10.1371/journal.pone.0259761.
Alkasaby MK, Abd El-Fattah AI, Ibrahim IH, Abd El-Samie HS. Polymorphism of XRCC3 in Egyptian breast cancer patients. Pharma Pers Med. 2020; 6: 273-282. https://doi.org/10.2147/PGPM.S260682.
Yu J, Wang CG. Relationship between polymorphisms in homologous recombination repair genes RAD51 G172T, XRCC2 & XRCC3 and risk of breast cancer: A meta-analysis. Front Onco. 2023; 13: 1047336. https://doi.org/10.3389/fonc.2023.1047336.
Hu J, Xu Z, Ye Z, Li J, Hao Z, Wang Y. The association between single nucleotide polymorphisms and ovarian cancer risk: A systematic review and network meta‐analysis. Cancer Med. 2023; 12(1): 541-556. https://doi.org/10.1002/cam4.4891.
Chiarella P, Capone P, Sisto R. Contribution of Genetic Polymorphisms in Human Health. Int J Environ Res Public Health. 2023; 20(2): 912. https://doi.org/10.3390/ijerph20020912.
Wonderen D, Melse-Boonstra A, Gerdessen JC. Iron bioavailability should be considered when modeling omnivorous, vegetarian, and vegan diets. J Nutr. 2023; 153(7): 2125-2132. https://doi.org/10.1016/j.tjnut.2023.05.011.
Ding J, Liu Q, Liu Z, Guo H, Liang J, Zhang Y. Associations of the dietary iron, copper, and selenium level with metabolic syndrome: a meta-analysis of observational studies. Front Nutr. 2022; 8: 810494. https://doi.org/10.3389/fnut.2021.810494.
González DR, González DÁ, Sayago A, Fernández RÁ. Recommendations and best practices for standardizing the pre-analytical processing of blood and urine samples in metabolomics. Metabolites. 2020; 10(6): 229. https://doi.org/10.3390/metabo10060229.
Zhang D, Xu P, Li Y, Wei B, Yang S, Zheng Y, et al. Association of vitamin C intake with breast cancer risk and mortality: A meta-analysis of observational studies. Aging (Albany NY). 2020; 12(18): 18415. https://doi.org/10.18632/aging.103769.
Jiang Q, Im S, Wagner JG, Hernandez ML, Peden DB. Gamma-tocopherol, a major form of vitamin E in diets: Insights into antioxidant and anti-inflammatory effects, mechanisms, and roles in disease management. Free Radic Biol Med. 2022; 178: 347-359. https://doi.org/10.1016/j.freeradbiomed.2021.12.012.
Zhu X, Pan D, Wang N, Wang S, Sun G. Relationship between selenium in human tissues and breast cancer: A meta-analysis based on case-control studies. Biol Trace Elem Res. 2021; 199: 4439–4446. https://doi.org/10.1007/s12011-021-02574-9.
Ali AM, AbdulKareem H, Al Anazi M, Reddy PN, Shaik JP, Alamri A, et al. Polymorphisms in DNA repair gene XRCC3 and susceptibility to breast cancer in Saudi females. BioMed Res Int. 2016; 2016(1): 8721052.https://doi.org/10.1155/2016/8721052.
Fakour F, Moghimi M, Esmaeilzadeh A, Kalantari F, Eskandari F, Biglari S, et al. Association between Plasma 25-Hydroxyvitamin D and Breast Cancer Risk: A Matched Case-Control Study. Middle East J Cancer 2022; 13(1): 81-88. https://doi.org/10.30476/mejc.2021.85406.1279.
Manocha A, Brockton NT, Cook L, Kopciuk KA. Low serum vitamin D associated with increased tumour size and higher grade in premenopausal Canadian women with breast cancer. Clin Breast Cancer. 2023; 23(6): e368-e376. https://doi.org/10.1016/j.clbc.2023.06.003.
Amjad A, Humayun S, Khan AH, Ayaz T, Batool W, Afridi F, et al. The Role of Vitamin D Deficiency as a Potential Risk Factor for Breast Cancer: A Case-Control Study. Pak J Med Helth Sci. 2023; 17(04): 572-575. https://doi.org/10.53350/pjmhs2023174572.
De Sousa FB, De Luca VH, Pessoa EC, Machado M, Nahas NJ, Nahas E. Vitamin D deficiency is associated with poor breast cancer prognostic features in postmenopausal women. J Steroid Biochem Mol Biol. 2017; 174: 284-289. https://doi.org/10.1016/j.jsbmb.2017.10.009.
Shamsi U, Khan S, Azam I, Khan AH, Maqbool A, Hanif M, et al .A multicenter case control study of association of vitamin D with breast cancer among women in Karachi, Pakistan. PLoS One. 2020; 15: e0225402.https://doi.org/10.1371/journal.pone.0225402.
Griñan LC, Blaya JL, López TA, Ávalos MM, Navarro OA, Cara FE, et al. Antioxidants for the treatment of breast cancer: Are we there yet? Antioxidants 2021; 10(2): 205. https://doi.org/10.3390/antiox10020205.
Didier AJ, Stiene J, Fang L, Watkins D, Dworkin LD, Creeden JF. Antioxidant and anti-tumor effects of dietary vitamins A, C, and E. Antioxidants 2023; 12(3): 632. https://doi.org/10.3390/antiox12030632.
Hussain AM, Ali AH, Mohammed HL. Correlation between serum and tissue markers in breast cancer Iraqi patients. Baghdad Sci J. 2022; 19(3): 0501-0514. https://doi.org/10.21123/bsj.2022.19.3.0501
Chang VC, Cotterchio M, Bondy SJ, Kotsopoulos J. Iron intake, oxidative stress‐related genes and breast cancer risk. Int J Cancer. 2020; 147(5): 1354-1373. https://doi.org/10.1002/ijc.32906.
Chang VC, Cotterchio M, Khoo E. Iron intake, body iron status, and risk of breast cancer: a systematic review and meta-analysis. BMC cancer. 2019; 19:1-28. https://doi.org/10.1186/s12885-019-5642-0.
Sacco A, Battaglia AM, Botta C, Aversa I, Mancuso S, Costanzo F, et al. Iron metabolism in the tumor microenvironment—Implications for anti-cancer immune response. Cells. 2021; 10(2): 303. https://doi.org/10.3390/cells10020303.
Alkasaby MK, Abd El-Fattah AI, Ibrahim IH, Abd El-Samie HS. Polymorphism of XRCC3 in Egyptian breast cancer patients. Pharmgeomics. Pers Med. 2020; 13: 273-282. https://doi.org/10.2147/PGPM.S260682.
Mao CF, Qіan WY, Wu JZ, Sun DW, Tang JH. Assocіation between the XRCC3 Thr241Met polymorphіsm and breast cancer risk: an updated meta-analysіs of 36 case-control studіes. Asian Pac J Cancer Prev. 2014; 15(16): 6613–6618. https://doi.org/10.7314/apjcp.2014.15.16.6613.
Gagno S, D’Andrea MR, Mansutti M, Zanusso C, Puglisi F, Dreussi E, et al. A new genetic risk score to predіct the outcome of locally advanced or metastatіc breast cancer patients treated with first-line exemestane: results from a prospectіve study. Clin Breast Cancer. 2019; 19(2): 137–145.e4. https://doi.org/10.1016/j. clbc.2018.11.00912.
Chai F, Liang Y, Chen L, Zhang F, Jiang J. Association between XRCC3 Thr241Met polymorphism and risk of breast cancer: meta-analysis of 23 case-control studies. Med Sci Monit. 2015; 21: 3231–3240.
Romanowіcz H, Pyziak Ł, Jabłońskі F, Bryś M, Forma E, Smolarz B. Analysіs of DNA repair genes polymorphіsms in breast cancer. Pathol Oncol Res. 2017; 23(1): 117–123.
Sliwinski T, Walczak A, Przybylowska K, Rusin P, Pietruszewska W, Zielinska-Blizniewska H,et al. Polymorphisms of the XRCC3 C722T and the RAD51 G135C genes and the risk of head and neck cancer in a Polish population. Exp Mol path. 2010; 89(3): 358-366. https://doi.org/10.1016/j.yexmp.2010.08.005.
Rajagopal T, Seshachalam A, Rathnam KK, Talluri S, Venkata BS, Dunna NR. Homologous recombination DNA repair gene RAD51, XRCC2 & XRCC3 polymorphisms and breast cancer risk in South Indian women. Plos one. 2022; 17(1): e0259761. https://doi.org/10.1371/journal.pone.0259761.
Yu J, Wang CG. Relationship between polymorphisms in homologous recombination repair genes RAD51 G172T, XRCC2 & XRCC3 and risk of breast cancer: A meta-analysis. Front. Oncol. 2023; 13: 01-15.https://doi.org/10.3389/fonc.2023.1047336.
Hu G, Gong LL, Chen YJ, Xu LH, Ye CM. Association between the XRCC3 rs861539 Polymorphism and Breast Cancer Risk: An Updated Meta-Analysis. Russ J Genet. 2023; 59(l2): S219-26. https://doi.org/10.1134/S1022795423140053
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