عقار الكولستين علاج احادي جيد لكبح جماح بكتريا الراكدة البومانية Acinetobacter baumannii خارج وداخل الجسم الحي

محتوى المقالة الرئيسي

Halah H. Al-Haideri
Nagham Saad Mohammed

الملخص

 


تعد بكتيريا Acinetobacter baumannii من احد مسببات الأمراض الانتهازية الرئيسية التي تقاوم العديد من المضادات الحيوية. الكوليستين هو مضاد حيوي يستخدم في الوقت الحاضر كطريقة  لمعالجة أخيرة للعزلات ذات المقاومة الشديدة. الغرض من هذه الدراسة هو التعرف على أهمية  جين LptD في الطبقه الدهنية LPS  من بكتريا A. baumannii ومعرفة دورها  الاساسي كعامل ضراوة.في الدراسة الحالية،  تم استخدام عزلتين من بكترياA.baumannii ، االعزلة المحلية HHR1 والعزلة العالمية ATCC 17904 ، وتم استخدام ثلاث انواع من المضادات الحياتية  (الكوليستين ،الريفامبيسين و  الفوسفوميسين كعلاج احادي او مزدوج خارج وداخل الجسم الحي.اظهرت النتائج أن A. baumannii HHR1 هي أكثر مقاومة لـ AMPs (Antimicrobial peptides) من السلالات العالمية ، تم ملاحظة ازدياد تأثير AMPs على A. baumannii بزيادة التركيز ووقت الحضانة ، كما تبين أيضًا أن AMPs تعتبر قاتله على بكتريا A. baumannii عند التركيز العالي (µg ml-12 ) في العلاج الأحادي و (1.5 ، 2 ) µg ml-1  في الدمج. علاوة على ذلك ، كانت حساسية العزلات متغايرة ، حيث اظهر الكولستين فعالية متميزة في تثبيط النمو البكتيري كعلاج احادي او عند المزج مع مضاد اخر.أظهرت النتائج أن التعبير الجيني لجينات lptD ، lptA للعزله المحلية أقل من العزلة القياسية بتركيز  2 µg ml-1 من الكوليستين ، بينما جين lptE كانت العزله القياسية  ذات  نمط تنظيم أعلى مما كان عليه في العزلة المحلية. علاوة على ذلك ، يؤثر الكوليستين على التصاق  A. baumannii على الخلايا الظهارية (A-549 خلية سرطان الرئة) ، وأظهر الكولستين تأثيرًا كبيرًا على نمو البكتيريا ، وتكاثر الخلايا ، عن طريق تقليل اعداد البكتيريا.

تفاصيل المقالة

كيفية الاقتباس
1.
عقار الكولستين علاج احادي جيد لكبح جماح بكتريا الراكدة البومانية Acinetobacter baumannii خارج وداخل الجسم الحي. Baghdad Sci.J [انترنت]. 1 أبريل، 2022 [وثق 17 مايو، 2024];19(2):0255. موجود في: https://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/5706
القسم
article

كيفية الاقتباس

1.
عقار الكولستين علاج احادي جيد لكبح جماح بكتريا الراكدة البومانية Acinetobacter baumannii خارج وداخل الجسم الحي. Baghdad Sci.J [انترنت]. 1 أبريل، 2022 [وثق 17 مايو، 2024];19(2):0255. موجود في: https://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/5706

المراجع

Al-Haideri HH. Gene Expression of blaOXA-51-like and blaOXA-23 in response to β-Lactam antibiotic in clinically isolates Acinetobacter baumanii and Acinetobacter lowffii from urine samples. Iraqi J Agric Sci. 2019;50(4).

Rebic V, Masic N, Teskeredzic S, Aljicevic M, Abduzaimovic A, Rebic D. The importance of acinetobacter species in the hospital environment. Med Arch. 2018;72(5):325.

Van Duin D, Paterson DL. Multidrug-resistant bacteria in the community: trends and lessons learned. Infectious Disease Clinics. 2016 Jun 1;30(2):377-90.

Xu L, Shao C, Li G, Shan A, Chou S, Wang J, Ma Q, Dong N. Conversion of broad-spectrum antimicrobial peptides into species-specific antimicrobials capable of precisely targeting pathogenic bacteria. Sci. Rep. 2020 Jan 22;10(1):1-9. اختصار اسم المجلة

Zanetti M. Cathelicidins, multifunctional peptides of the innate immunity. J Leukoc Biol. 2004;75(1):39–48.

Lei J, Sun L, Huang S, Zhu C, Li P, He J, et al. The antimicrobial peptides and their potential clinical applications. Am J Transl Res. 2019;11(7):3919.

Dong H, Zhang Z, Tang X, Paterson NG, Dong C. Structural and functional insights into the lipopolysaccharide ABC transporter LptB 2 FG. Nat Commun. 2017;8(1):1–11.

Janssen AB, Bartholomew TL, Marciszewska NP, Bonten MJ, Willems RJ, Bengoechea JA, et al. Nonclonal Emergence of Colistin Resistance Associated with Mutations in the BasRS Two-Component System in Escherichia coli Bloodstream Isolates. Msphere. 2020 Apr 29;5(2).

Bialvaei AZ, Samadi Kafil H. Colistin, mechanisms and prevalence of resistance. Curr Med Res Opin. 2015;31(4):707–21.

Biswas S, Brunel J-M, Dubus J-C, Reynaud-Gaubert M, Rolain J-M. Colistin: an update on the antibiotic of the 21st century. Expert Rev Anti Infect Ther. 2012;10(8):917–34.

Li Z, Cao Y, Yi L, Liu JH, Yang Q. Emergent polymyxin resistance: end of an era?. InOpen forum infectious diseases 2019 Oct (Vol. 6, No. 10, p. ofz368). US: Oxford University Press.

Bialvaei AZ, Kafil HS, Asgharzadeh M, Yousef Memar M, Yousefi M. Current methods for the identification of carbapenemases. J Chemother. 2016;28(1):1–19.

Lee HJ, Bergen PJ, Bulitta JB, Tsuji B, Forrest A, Nation RL, et al. Synergistic activity of colistin and rifampin combination against multidrug-resistant Acinetobacter baumannii in an in vitro pharmacokinetic/pharmacodynamic model. Antimicrob Agents Chemother. 2013;57(8):3738–45.

Leelasupasri S, Santimaleeworagun W, Jitwasinkul T. Antimicrobial susceptibility among colistin, sulbactam, and fosfomycin and a synergism study of colistin in combination with sulbactam or fosfomycin against clinical isolates of carbapenem-resistant Acinetobacter baumannii. J Pathog. 2018;2018.

Hamzah AS. Genetic Variations in rplB Gene Associated with Multidrug Resistance Acinetobacter baumannii Isolated from Different Clinical Sources. Al-Nahrain J Sci. 2018;21(3):119–25.

Al-Haideri H. Characterization of novel proteins in the cell envelope of Campylobacter jejuni A thesis submitted in part fulfilment for the degree of Doctor of Philosophy. Department of Molecular Biology and Biotechnology, The University of Sheffield. 2015;(March).

Kadhim WKA, Nayef UM, Jabir MS. Polyethylene glycol-functionalized magnetic (Fe3O4) nanoparticles: A good method for a successful antibacterial therapeutic agent via damage DNA molecule. Surf Rev Lett. 2019;26(10):1–15.

Al-Shammari AM, Alshami MA, Umran MA, Almukhtar AA, Yaseen NY, Raad K, et al. Establishment and characterization of a receptor-negative, hormone-nonresponsive breast cancer cell line from an Iraqi patient. Breast Cancer Targets Ther. 2015;7:223.

Aghapour Z, Gholizadeh P, Ganbarov K, Bialvaei AZ, Mahmood SS, Tanomand A, et al. Molecular mechanisms related to colistin resistance in Enterobacteriaceae. Infect Drug Resist. 2019;12:965.

Li J, Rayner CR, Nation RL, Owen RJ, Spelman D, Tan KE, et al. Heteroresistance to colistin in multidrug-resistant Acinetobacter baumannii. Antimicrob Agents Chemother. 2006;50(9):2946–50.

Hernan RC, Karina B, Gabriela G, Marcela N, Carlos V, Angela F. Selection of colistin-resistant Acinetobacter baumannii isolates in postneurosurgical meningitis in an intensive care unit with high presence of heteroresistance to colistin. Diagn Microbiol Infect Dis. 2009;65(2):188–91.

Tan C-H, Li J, Nation RL. Activity of colistin against heteroresistant Acinetobacter baumannii and emergence of resistance in an in vitro pharmacokinetic/pharmacodynamic model. Antimicrob Agents Chemother. 2007;51(9):3413–5.

Yu X-H, Song X-J, Cai Y, Liang B-B, Lin D-F, Wang R. In vitro activity of two old antibiotics against clinical isolates of methicillin-resistant Staphylococcus aureus. J Antibiot (Tokyo). 2010;63(11):657–9.

Bai Y, Liu B, Wang T, Cai Y, Liang B, Wang R, et al. In vitro activities of combinations of rifampin with other antimicrobials against multidrug-resistant Acinetobacter baumannii. Antimicrob Agents Chemother. 2015 Mar 1;59(3):1466-71.

Vázquez-López R, Solano-Gálvez SG, Juárez Vignon-Whaley JJ, Abello Vaamonde JA, Padró Alonzo LA, Rivera Reséndiz A, et al. Acinetobacter baumannii Resistance: A Real Challenge for Clinicians. Antibiotics. 2020 Apr;9(4):205.

Asif M, Alvi IA, Rehman SU. Insight into Acinetobacter baumannii: pathogenesis, global resistance, mechanisms of resistance, treatment options, and alternative modalities. Infect. and drug resist. 2018;11:1249.

Krishnamurthy M, Lemmon MM, Falcinelli EM, Sandy RA, Dootz JN, Mott TM, et al. Enhancing the antibacterial activity of polymyxins using a nonantibiotic drug. Infec. and Drug Resis.. 2019;12:1393.

Kheshti R, Pourabbas B, Mosayebi M, Vazin A. In vitro activity of colistin in combination with various antimicrobials against Acinetobacter baumannii species, a report from South Iran. Infec. and Drug Resist.. 2019;12:129.

Giannouli M, Di Popolo A, Durante-Mangoni E, Bernardo M, Cuccurullo S, Amato G, et al. Molecular epidemiology and mechanisms of rifampicin resistance in Acinetobacter baumannii isolates from Italy. Int J Antimicrob Agents. 2012;39(1):58–63.

Cheah S-E, Li J, Tsuji BT, Forrest A, Bulitta JB, Nation RL. Colistin and polymyxin B dosage regimens against Acinetobacter baumannii: differences in activity and the emergence of resistance. Antimicrob Agents Chemother. 2016;60(7):3921–33.

Rigatto MH, Oliveira MS, Perdigão-Neto L V, Levin AS, Carrilho CM, Tanita MT, et al. Multicenter prospective cohort study of renal failure in patients treated with colistin versus polymyxin B. Antimicrob Agents Chemother. 2016;60(4):2443–9.

Parker SL, Frantzeskaki F, Wallis SC, Diakaki C, Giamarellou H, Koulenti D, et al. Population pharmacokinetics of fosfomycin in critically ill patients. Antimicrob Agents Chemother. 2015;59(10):6471–6.

Nastro M, Rodríguez CH, Monge R, Zintgraff J, Neira L, Rebollo M, et al. Activity of the colistin–rifampicin combination against colistin-resistant, carbapenemase-producing Gram-negative bacteria. J Chemother. 2014;26(4):211–6.

Poirel L, Jayol A, Nordmann P. Polymyxins: antibacterial activity, susceptibility testing, and resistance mechanisms encoded by plasmids or chromosomes. Clin Microbiol Rev. 2017 Apr 1;30(2):557-96.

Wehrli W. Rifampin: mechanisms of action and resistance. Rev Infect Dis. 1983;5(Supplement_3):S407–11.

Hancock REW, Chapple DS. Peptide antibiotics. Antimicrob Agents Chemother. 1999;43(6):1317–23.

Cafiso V, Stracquadanio S, Lo Verde F, Gabriele G, Mezzatesta ML, Caio C, et al. Colistin resistant Acinetobacter. baumannii: genomic and transcriptomic traits acquired under colistin therapy. Front Microbiol . 2019 Jan 7;9:3195.

Henry R, Vithanage N, Harrison P, Seemann T, Coutts S, Moffatt JH, et al. Colistin-resistant, lipopolysaccharide-deficient Acinetobacter baumannii responds to lipopolysaccharide loss through increased expression of genes involved in the synthesis and transport of lipoproteins, phospholipids, and poly-β-1, 6-N-acetylglucosamine. Antimicrob Agents Chemother. 2012;56(1):59–69.

Ko KS, Suh JY, Kwon KT, Jung S-I, Park K-H, Kang CI, et al. High rates of resistance to colistin and polymyxin B in subgroups of Acinetobacter baumannii isolates from Korea. J Antimicrob Chemother. 2007;60(5):1163–7.

Park YJ, Hong DJ, Yoon EJ, Kim D, Choi MH, Hong JS, et al. Differences in Colistin-resistant Acinetobacter baumannii Clinical Isolates Between Patients With and Without Prior Colistin Treatment. Annals of laboratory medicine. 2018 Nov;38(6):545-54.

Adams MD, Nickel GC, Bajaksouzian S, Lavender H, Murthy AR, Jacobs MR, et al. Resistance to colistin in Acinetobacter baumannii associated with mutations in the PmrAB two-component system. Antimicrob Agents Chemother. 2009;53(9):3628–34.

López-Rojas R, Jiménez-Mejías ME, Lepe JA, Pachón J. Acinetobacter baumannii resistant to colistin alters its antibiotic resistance profile: a case report from Spain. J Infect Dis. 2011;204(7):1147–8.

Vrancianu CO, Pelcaru CF, Alistar A, Gheorghe I, Marutescu L, Popa M, et al. Escaping from ESKAPE. Clinical Significance and Antibiotic Resistance Mechanisms in Acinetobacter baumannii: a Review. Biointerface Research in Applied Chemistry.Biointerface Reserch in Applied chemistry. 2020 jul 11(1),8190-8203.

Hood MI, Jacobs AC, Sayood K, Dunman PM, Skaar EP. Acinetobacter baumannii increases tolerance to antibiotics in response to monovalent cations. Antimicrob Agents Chemother. 2010;54(3):1029–41.

He X, Lu F, Yuan F, Jiang D, Zhao P, Zhu J, et al. Biofilm formation caused by clinical Acinetobacter baumannii isolates is associated with overexpression of the AdeFGH efflux pump. Antimicrob Agents Chemother. 2015;59(8):4817–25.

Bojkovic J, Richie DL, Six DA, Rath CM, Sawyer WS, Hu Q, et al. Characterization of an Acinetobacter baumannii lptD deletion strain: permeability defects and response to inhibition of lipopolysaccharide and fatty acid biosynthesis. J Bacteriol. 2016;198(4):731–41.

Whitfield C, Trent MS. Biosynthesis and export of bacterial lipopolysaccharides. Annu Rev Biochem. 2014;83:99–128.

Nhu NTK, Riordan DW, Nhu TDH, Thanh DP, Thwaites G, Lan NPH, et al. The induction and identification of novel Colistin resistance mutations in Acinetobacter baumannii and their implications. Sci Rep. 2016;6(1):1–8.

El-Sayed Ahmed MAE-G, Zhong L-L, Shen C, Yang Y, Doi Y, Tian G-B. Colistin and its role in the Era of antibiotic resistance: an extended review (2000–2019). Emerg Microbes Infect. 2020;9(1):868–85.

Zhang G, Baidin V, Pahil KS, Moison E, Tomasek D, Ramadoss NS, et al. Cell-based screen for discovering lipopolysaccharide biogenesis inhibitors. Proc Natl Acad Sci. 2018;115(26):6834–9.

Longo F, Vuotto C, Donelli G. Biofilm formation in Acinetobacter baumannii. New Microbiol. 2014;37(2):119–27.

Pérez A, Merino M, Rumbo-Feal S, Álvarez-Fraga L, Vallejo JA, Beceiro A, et al. The FhaB/FhaC two-partner secretion system is involved in adhesion of Acinetobacter baumannii AbH12O-A2 strain. Virulence. 2017;8(6):959–74.

Schweppe DK, Harding C, Chavez JD, Wu X, Ramage E, Singh PK, et al. Host-microbe protein interactions during bacterial infection. Chem Biol. 2015;22(11):1521–30.

Nie D, Hu Y, Chen Z, Li M, Hou Z, Luo X, et al. Outer membrane protein A (OmpA) as a potential therapeutic target for Acinetobacter baumannii infection. Int J Biomed Sc. 2020 Dec 1;27(1):26.

Berghmans T, Sculier J-P, Klastersky J. A prospective study of infections in lung cancer patients admitted to the hospital. Chest. 2003;124(1):114–20.

Pietrocola G, Arciola CR, Rindi S, Di Poto A, Missineo A, Montanaro L, et al. Toll-like receptors (TLRs) in innate immune defense against Staphylococcus aureus. Int J Artif Organs. 2011;34(9):799–810.

Chattopadhyay S, Veleeparambil M, Poddar D, Abdulkhalek S, Bandyopadhyay SK, Fensterl V, et al. EGFR kinase activity is required for TLR4 signaling and the septic shock response. EMBO Rep. 2015;16(11):1535–47.

Hattar K, Savai R, Subtil FSB, Wilhelm J, Schmall A, Lang DS, et al. Endotoxin induces proliferation of NSCLC in vitro and in vivo: role of COX-2 and EGFR activation. Cancer Immunol Immunother. 2013;62(2):309–20.

Malaise EP, Fertil B, Chavaudra N, Guichard M. Distribution of radiation sensitivities for human tumor cells of specific histological types: comparison of in vitro to in vivo data. Int J Radiat Oncol Biol Phys. 1986;12(4):617–24.

Krause M, Dubrovska A, Linge A, Baumann M. Radioresistance, prediction of radiotherapy outcome and specific targets for combined treatments. Adv Drug Deliv Rev. 2017;109:63–73.

المؤلفات المشابهة

يمكنك أيضاً إبدأ بحثاً متقدماً عن المشابهات لهذا المؤلَّف.