الالتحام الجزيئي في تحضير وتقييم النشاط كمضادات أكسدة ومضادات بكتيرية لمشتقات الاوكسازيبان و وبنزواوكسازيبين الجديدة

المؤلفون

DOI:

https://doi.org/10.21123/bsj.2023.8553

الكلمات المفتاحية:

مضادات اكسدة، بنزواوكسازبين ، الفعالية، الارساء، الاوكسازببان

الملخص

يعد الالتحام  الجزيئي طريقة  في مجال المحاكاة الجزيئية يمكن خلالها تحديد الاتجاه الأمثل والمفضل  لارتباط جزيء معين بجزيء آخر عندما يكونان  معقد مستقر. و من معرفة  الالتحام يمكن التنبؤ بقوة الارتباط أو تقارب الارتباط المفضل  بين الجزيئين.  في هذه الدراسة ، تم تقييم  سلسلة من المركبات المحضرة ومعرفة وضعيات  الربط والتفاعلات المحتملة ومواقع الربط المستهدفة. حضرت  بعض مشتقات 1، 3-أوكسازيبان و 1،3-بنزوكسازيبين من ثلاثة مركبات لقواعد شيف  .(3S-1S) تم تفاعل المركبات مع  (3S-1S  أنهيدريد السكسينيك و أنهيدريد الفثاليك للحصول على مشتقات 1،3- أوكسازيبان و 1،3-بنزوكسازيبين .(3C-1B)  شخصت المركبات المحضرة من خلال طرق تحليل العناصر  و الاشعة تحت الحمراء FT-IR  و وطيف الرنين النووي المغناطيسي   1H-13CNMR  تم تسجيل النشاط المضاد للبكتيريا للمركبات  (1 B-3C) ضد بعض البكتيريا المعزولة بما في ذلك البكتيريا سالبة الجرام   (المكورات العنقودية الذهبية  ) و موجبة الجرام  (البكتريا القولونية) مع  استخدام الاموكسيلين  كدواء مرجع. أظهرت المركبات  (1B-3C)قيمًا جيدة مثل فعاليتها  من المتوسطة الى المرتفعة ضد سلالات البكتيريا المستخدمة. علاوة على ذلك ، تم تقييم النشاط المضاد للأكسدة للمركبات المصنعة (1B-3C) باستخدام 2،2-.ثنائي فنيل 1-1-بيكريل هدرازين و أظهرت النتائج أن المركبات لها أعلى القيم كقانص جذور حرة .

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كيفية الاقتباس

1.
الالتحام الجزيئي في تحضير وتقييم النشاط كمضادات أكسدة ومضادات بكتيرية لمشتقات الاوكسازيبان و وبنزواوكسازيبين الجديدة. Baghdad Sci.J [انترنت]. [وثق 17 مايو، 2024];21(7). موجود في: https://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/8553