الالتحام الجزيئي في تحضير وتقييم النشاط كمضادات أكسدة ومضادات بكتيرية لمشتقات الاوكسازيبان و وبنزواوكسازيبين الجديدة
محتوى المقالة الرئيسي
الملخص
يعد الالتحام الجزيئي طريقة في مجال المحاكاة الجزيئية يمكن خلالها تحديد الاتجاه الأمثل والمفضل لارتباط جزيء معين بجزيء آخر عندما يكونان معقد مستقر. و من معرفة الالتحام يمكن التنبؤ بقوة الارتباط أو تقارب الارتباط المفضل بين الجزيئين. في هذه الدراسة ، تم تقييم سلسلة من المركبات المحضرة ومعرفة وضعيات الربط والتفاعلات المحتملة ومواقع الربط المستهدفة. حضرت بعض مشتقات 1، 3-أوكسازيبان و 1،3-بنزوكسازيبين من ثلاثة مركبات لقواعد شيف .(3S-1S) تم تفاعل المركبات مع (3S-1S أنهيدريد السكسينيك و أنهيدريد الفثاليك للحصول على مشتقات 1،3- أوكسازيبان و 1،3-بنزوكسازيبين .(3C-1B) شخصت المركبات المحضرة من خلال طرق تحليل العناصر و الاشعة تحت الحمراء FT-IR و وطيف الرنين النووي المغناطيسي 1H-13CNMR تم تسجيل النشاط المضاد للبكتيريا للمركبات (1 B-3C) ضد بعض البكتيريا المعزولة بما في ذلك البكتيريا سالبة الجرام (المكورات العنقودية الذهبية ) و موجبة الجرام (البكتريا القولونية) مع استخدام الاموكسيلين كدواء مرجع. أظهرت المركبات (1B-3C)قيمًا جيدة مثل فعاليتها من المتوسطة الى المرتفعة ضد سلالات البكتيريا المستخدمة. علاوة على ذلك ، تم تقييم النشاط المضاد للأكسدة للمركبات المصنعة (1B-3C) باستخدام 2،2-.ثنائي فنيل 1-1-بيكريل هدرازين و أظهرت النتائج أن المركبات لها أعلى القيم كقانص جذور حرة .
Received 09/02/2023
Revised 22/05/2023
Accepted 24/05/2023
Published Online First 25/12/2023
تفاصيل المقالة
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كيفية الاقتباس
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