تقييم الفعاليات المضادة للاكسدة والبكتريا والسكري لمستخلص البردقوش الكحولي - المائي

المؤلفون

  • Kadhim K. Ghudhaib قسم الكيمياء، كلية العلوم للبنات، جامعة بغداد، بغداد، العراق. https://orcid.org/0000-0003-4966-4070
  • Fayhaa M. Khaleel قسم الكيمياء، كلية العلوم للبنات، جامعة بغداد، بغداد، العراق.

DOI:

https://doi.org/10.21123/bsj.2024.9328

الكلمات المفتاحية:

الفعالبة المضادة للبكتريا، الفعالية المضادة للسكري، الفعالية المضادة للفطريات،الفعالية المضادة للاكسدة،مستخلص البردقوش

الملخص

تمتلك المستخلصات النباتية أهمية خاصة تجاه صحة الإنسان والأنشطة الحيوية لمجموعة واسعة من الأمراض. هدفت الدراسة الحالية إلى التحقق من وجود مكونات فعالة في مستخلص أوراق البردقوش ، وتحديد مضادات الأكسدة ، والأنشطة المضادة للبكتيريا والفطريات ، و LD50 ونشاطها المضاد لمرض السكر. تم تحليل المكونات النشطة نوعيا من خلال طرائق اختبار محددة. وتم قياس الأنشطة المضادة للأكسدة ، LD50 ، مضادات البكتريا والفطريات بالطرائق القياسية. وحددت  الفعالية المضادة للسكري  عن طريق تقييم ارتفاع السكر   وفرط شحميات الدم ووظائف الكبد بالطرائق الطيفية. اكدت  النتائج على وجود العديد من المكونات الفعالة تتضمن مركبات الفلافونويد والقلويدات والتربينويدات والعفص والصابونين. كما أظهرت نتائج فعالية مضادات الأكسدة أن مستخلص أوراق البردقوش يمتلك نشاطًا مضادًا للأكسدة مشابهًا  لحمض الأسكوربيك. وأظهرت نتائج LD50 أن الجرعة المسموح بها هي 12.5 ملغم / مل. أشارت نتائج الفعالية الحيوية إلى أن مستخلص أوراق البردقوش يمتلك فعالية مضادة  لمدى واسع من البكتريا والفطريات المرضية ،  ولكن لا يوجد تأثير للمستخلص على E. coli و Staphylococcus aureus حتى عند التراكيز العالية. أظهر مستخلص البردقوش فعالية عاليًة مضادًا  للسكري عند المعالجته لمدة أسبوعين بـ  4 ملغم من المستخلص يوميا. مع تحسن مستوى الدهون ووظائف الكبد ومستويات هرمون التستوستيرون بعد العلاج في مجموعة مرضى السكري مقارنة مع مجموعة التحكم. يمكن الاستنتاج أن مستخلص أوراق البردقوش يحتوي على فعالية عالية مضادة للأكسدة  مع فعالية حيوية عالية ضد البكتريا والفطريات المرضية ونشاط عال مضاد  للسكري مع تعزيز كبير للخصوبة ومستوى عالٍ من الجرعات المسموح بها وفقًا لقيمة LD50.

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تقييم الفعاليات المضادة للاكسدة والبكتريا والسكري لمستخلص البردقوش الكحولي - المائي. Baghdad Sci.J [انترنت]. [وثق 21 مايو، 2024];21(8). موجود في: https://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/9328